CK934275

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: SIK2_HUMAN (Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1)

HSP 1 Score: 201.83 bits (512), Expect = 3.990e-51
Identity = 104/214 (48.60%), Postives = 143/214 (66.82%), Query Frame = 3

Query:  216 RVGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            RVG Y++  TLG+G+FA VK  ++  T   VAIKI+D+ Q L    +E+I RE+  MK++ HP++IK+ +VM +K+ +Y+V E+   GE+FD +A HGRL E EARR F Q+++AVDYCH R + HRDLK ENLLLD+   +KI+DFG        +   LL T CG+P Y APEV   + Y+G   D+WS GV+L+VL+ G LPFD   L  L
Sbjct:   16 RVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQ-LDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNF---FKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPIL 225          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: SIK2_CHICK (Serine/threonine-protein kinase SIK2 OS=Gallus gallus GN=SIK2 PE=2 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 1.161e-50
Identity = 107/230 (46.52%), Postives = 148/230 (64.35%), Query Frame = 3

Query:  180 EKMSVKVPASRT----RVGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            E  SV  P++      RVG Y++ RTLG+G+FA VK A++  T   VAIKI+D+ + L    +E+I RE+  MKL+ HP++IK+ +VM +K  +YIV EF   GE+FD +  +G L E EAR+ F Q+++AV+YCHS  + HRDLK ENLLLD+   +K++DFG        +    L T CG+P Y APEV   K Y+G   D+WS GV+L+VL+ G LPFD  NL  L
Sbjct:    6 EDASVPAPSAAQPRPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR-LDPSNLEKIYREVQIMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDHLTSNGHLSESEARKKFWQILSAVEYCHSHHIVHRDLKTENLLLDANMNIKLADFGFGNF---YKSGEPLSTWCGSPPYAAPEVFEGKEYEGPHLDIWSLGVVLYVLVCGSLPFDGPNLPTL 231          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: RKIN1_SECCE (Carbon catabolite-derepressing protein kinase OS=Secale cereale GN=RKIN1 PE=2 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 1.161e-50
Identity = 105/211 (49.76%), Postives = 146/211 (69.19%), Query Frame = 3

Query:  228 YELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKL---IKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDG-LLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNL 848
            Y LG+ LG G+FAKV  A++  T   VAIK+++R Q+   +M E+ KREI  ++L   + HP++I++ EV+ +   I++V+E+   G+L D I +  RL+EDEARR FQQ+I+AV+YCH   V HRDLKPENLLLDS   +K++DFGLS     V  DG  L T+CG+ NY APEV++ K Y G   DVWSCGVIL+ L+ G +PFD+ N+
Sbjct:   14 YYLGKILGVGTFAKVIIAEHKHTRHKVAIKVLNRRQMRAPEMEEKAKREIKILRLFIDLIHPHIIRVYEVIVTPKDIFVVMEYCQNGDLLDYILEKRRLQEDEARRTFQQIISAVEYCHRNKVVHRDLKPENLLLDSKYNVKLADFGLS----NVMHDGHFLKTSCGSLNYAAPEVISGKLYAGPEIDVWSCGVILYALLCGAVPFDDDNI 220          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: MELK_HUMAN (Maternal embryonic leucine zipper kinase OS=Homo sapiens GN=MELK PE=1 SV=3)

HSP 1 Score: 200.29 bits (508), Expect = 1.161e-50
Identity = 102/210 (48.57%), Postives = 142/210 (67.62%), Query Frame = 3

Query:  228 YELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            YEL  T+G G FAKVK A ++ TG+ VAIKI+D++ +     + +IK EI  +K ++H ++ ++  V+ +  KI++VLE+  GGELFD I    RL E+E R  F+Q+++AV Y HS+G  HRDLKPENLL D Y  LK+ DFGL A   +  +D  L T CG+  Y APE++  K Y G  +DVWS G++L+VLM GFLPFD+ N+MAL
Sbjct:   11 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTL--GSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCA-KPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMAL 217          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: SIK1_RAT (Serine/threonine-protein kinase SIK1 OS=Rattus norvegicus GN=Sik1 PE=2 SV=1)

HSP 1 Score: 199.904 bits (507), Expect = 1.516e-50
Identity = 103/214 (48.13%), Postives = 142/214 (66.36%), Query Frame = 3

Query:  216 RVGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            RVG Y++ RTLG+G+FA VK A++  T   VAIKI+D+ + L    +E+I RE+  MKL+ HPN+IK+ +VM +K  +YIV EF   GE+FD +  +G L E+EAR+ F Q+++AV+YCH+  + HRDLK ENLLLD    +K++DFG        +    L T CG+P Y APEV   K Y+G   D+WS GV+L+VL+ G LPFD  NL  L
Sbjct:   23 RVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR-LDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHNHHIVHRDLKTENLLLDGNMDIKLADFGFGNF---YKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTL 232          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: MARK3_HUMAN (MAP/microtubule affinity-regulating kinase 3 OS=Homo sapiens GN=MARK3 PE=1 SV=3)

HSP 1 Score: 199.519 bits (506), Expect = 1.980e-50
Identity = 102/236 (43.22%), Postives = 148/236 (62.71%), Query Frame = 3

Query:  219 VGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQ-----------------------LINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            +G Y L +T+G+G+FAKVK A+++ TG  VAIKI+D+ Q L    ++++ RE+  MK++ HPN++K+ EV+ ++  +Y+++E+  GGE+FD +  HGR+KE EAR  F+Q                       +++AV YCH + + HRDLK ENLLLD+   +KI+DFG    S +    G L T CG+P Y APE+   K YDG   DVWS GVIL+ L++G LPFD  NL  L
Sbjct:   53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQ-LNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKVQVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFG---FSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKEL 284          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: SIK1_MOUSE (Serine/threonine-protein kinase SIK1 OS=Mus musculus GN=Sik1 PE=1 SV=2)

HSP 1 Score: 198.749 bits (504), Expect = 3.378e-50
Identity = 104/214 (48.60%), Postives = 142/214 (66.36%), Query Frame = 3

Query:  216 RVGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            RVG Y++ RTLG+G+FA VK A++  T   VAIKI+D+ + L    +E+I RE+  MKL+ HPN+IK+ +VM +K  +YIV EF   GE+FD +  +G L E+EAR+ F Q+++AV+YCH+  + HRDLK ENLLLDS   +K++DFG        +    L T  G+P Y APEV   K Y+G   DVWS GV+L+VL+ G LPFD  NL  L
Sbjct:   23 RVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR-LDSSNLEKIYREVQLMKLLNHPNIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDSNMDIKLADFGFGNF---YKPGEPLSTCVGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVLVCGSLPFDGPNLPTL 232          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: MELK_MOUSE (Maternal embryonic leucine zipper kinase OS=Mus musculus GN=Melk PE=1 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 3.378e-50
Identity = 102/210 (48.57%), Postives = 142/210 (67.62%), Query Frame = 3

Query:  228 YELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            YEL  T+G G FAKVK A +V TG+ VAIKI+D++ +     + ++K EI  +K ++H ++ ++  V+ +K KI++VLE+  GGELFD I    RL E+E R  F+Q+++AV Y HS+G  HRDLKPENLL D    LK+ DFGL A   +  +D  L T CG+  Y APE++  K Y G  +DVWS G++L+VLM GFLPFD+ N+MAL
Sbjct:   11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNAL--GSDLPRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCA-KPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMAL 217          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: GIN4_YEAST (Serine/threonine-protein kinase GIN4 OS=Saccharomyces cerevisiae GN=GIN4 PE=1 SV=1)

HSP 1 Score: 198.749 bits (504), Expect = 3.378e-50
Identity = 103/231 (44.59%), Postives = 147/231 (63.64%), Query Frame = 3

Query:  198 VPASRTR-VGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDR--------------DQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESN 845
            +PA +   +G ++LG TLG GS  KV+ A+N  TG   A+K++ +                     +   I+REI  MKL+ HPNV+++ +V  + T +Y+VLE+ + GELF+ + + G L E EA R+F+Q+I  V YCH+ G+ HRDLKPENLLLD    +KI+DFG++A+     E  LL T+CG+P+Y APE+++   Y G ASDVWSCGVILF L+ G LPFDE +
Sbjct:    8 IPAIKDNTIGPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTSIVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAALE---TEGKLLETSCGSPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEED 235          

BLAST of CK934275 vs. ExPASy Swiss-Prot
Match: SIK1_HUMAN (Serine/threonine-protein kinase SIK1 OS=Homo sapiens GN=SIK1 PE=1 SV=2)

HSP 1 Score: 198.364 bits (503), Expect = 4.412e-50
Identity = 102/214 (47.66%), Postives = 141/214 (65.89%), Query Frame = 3

Query:  216 RVGKYELGRTLGEGSFAKVKFAKNVETGDFVAIKIVDRDQVLRHKMVEQIKREISTMKLIKHPNVIKIIEVMASKTKIYIVLEFIDGGELFDKIAKHGRLKEDEARRYFQQLINAVDYCHSRGVFHRDLKPENLLLDSYGVLKISDFGLSAISQQVREDGLLHTACGTPNYVAPEVLNDKGYDGRASDVWSCGVILFVLMAGFLPFDESNLMAL 857
            RVG Y++ RTLG+G+FA VK A++  T   VAIKI+D+ + L    +E+I RE+  MKL+ HP++IK+ +VM +K  +YIV EF   GE+FD +  +G L E+EAR+ F Q+++AV+YCH   + HRDLK ENLLLD    +K++DFG        +    L T CG+P Y APEV   K Y+G   D+WS GV+L+VL+ G LPFD  NL  L
Sbjct:   23 RVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR-LDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGNMDIKLADFGFGNF---YKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTL 232