EY728674

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: MKKA_DICDI (Mitogen-activated protein kinase kinase kinase A OS=Dictyostelium discoideum GN=mkkA PE=1 SV=2)

HSP 1 Score: 100.138 bits (248), Expect = 1.821e-20
Identity = 61/174 (35.06%), Postives = 103/174 (59.20%), Query Frame = 1

Query:  196 EKLQVLGHGNGGTVYKVQHRCTLKIYALK---VVHGDADPTVRRQVF---REMEILRRTDSPFIVQCFGIFEKPSGDIAILMEYMDSGTLDTLLNKNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPE 699
            +K Q+LG G  G+VY   ++ T +++A+K   +V  ++DP ++  +    +E+E++R      IV+  G     S  +++ +EY+  G++ +LL K G FSE  +     QIL+GLS+LH + IIHRDIK +N+L++   + VK++DFG SK     +    S  GT  +M+PE
Sbjct:  171 QKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSF-LSVFLEYIPGGSISSLLGKFGAFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGI-VKLSDFGCSKSFSGIVSQFKSMQGTPYWMAPE 342          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: M4K4_HUMAN (Mitogen-activated protein kinase kinase kinase kinase 4 OS=Homo sapiens GN=MAP4K4 PE=1 SV=2)

HSP 1 Score: 99.7525 bits (247), Expect = 2.378e-20
Identity = 64/196 (32.65%), Postives = 110/196 (56.12%), Query Frame = 1

Query:  196 EKLQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRR-TDSPFIVQCFGIFEKPS-----GDIAILMEYMDSGTLDTLLN--KNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPERFDPDXXXXXXXXXXXDIWS 759
            E ++V+G+G  G VYK +H  T ++ A+KV+  D       ++  E+ +L++ +    I   +G F K S       + ++ME+  +G++  L+   K  T  E  +A+I+ +IL+GL++LH H +IHRDIK  N+L+   N +VK+ DFGVS  + R++   N+++GT  +M+PE    D           D+WS
Sbjct:   26 ELVEVVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLL-TENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWS 218          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: CST1_CAEEL (Serine/threonine-protein kinase cst-1 OS=Caenorhabditis elegans GN=cst-1 PE=2 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 2.378e-20
Identity = 63/199 (31.66%), Postives = 109/199 (54.77%), Query Frame = 1

Query:  211 LGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRTDSPFIVQCFGIFEKPSGDIAILMEYMDSGTLDTLLN-KNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPERFDPDXXXXXXXXXXXDIWSXXXXXXXXXXGHFPF 804
            LG G+ G+V+K  HR +  + A+K V  D D    +++ +E+ I+++  S ++V+ +G + K S D+ I+MEY  +G++  ++  +    SE +++ +    LKGL YLH  K IHRDIK  N+L+N + +  K+ADFGV+  +  ++   N+ +GT  +M+PE  +             DIWS          G  P+
Sbjct:   41 LGEGSYGSVHKAIHRESGHVLAIKKVPVDTD---LQEIIKEISIMQQCKSKYVVKYYGSYFKHS-DLWIVMEYCGAGSISDIMRARRKPLSEQEISAVLRDTLKGLQYLHDLKKIHRDIKAGNILLNTDGI-AKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIE-----EIGYDTKADIWSLGITAIEMAEGRPPY 229          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: PPK11_SCHPO (Serine/threonine-protein kinase ppk11 OS=Schizosaccharomyces pombe GN=ppk11 PE=2 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 3.106e-20
Identity = 64/166 (38.55%), Postives = 95/166 (57.23%), Query Frame = 1

Query:  202 LQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRTDSPFIVQCFGIFEKPSGDIAILMEYMDSGTLDTLLNKNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPE 699
            LQ++G G+ G+V++ Q   + KI ALKVV  DA       + +E+  L   +S  I + +  F      + I MEY D G+   LL  +GTFSE  +A +  Q+L+ L YLHG   +HRDIK +N+L   + + VK+ADFGVS  +    D  + +VGT  +M+PE
Sbjct:    9 LQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKYYASFVD-GFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDIKAANILTMKDGL-VKLADFGVSGQLESLRDKNDDFVGTPFWMAPE 172          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: SVKA_DICDI (Serine/threonine-protein kinase svkA OS=Dictyostelium discoideum GN=svkA PE=1 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 4.057e-20
Identity = 64/174 (36.78%), Postives = 103/174 (59.20%), Query Frame = 1

Query:  190 DLEKLQV----LGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRTDSPFIVQCFGIFEKPSGDIAILMEYMDSGTLDTLLNKNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPE 699
            D E+L V    +G G+ G V+K  ++ T +  A+K +  +        + +E+ +L + +SPF+ + FG F K S  + I+MEY+  G++  L+ K G F E  +A I  ++LKGL YLH    IHRDIK +N+L++ +   VK+ADFGVS  +   +   N++VGT  +M+PE
Sbjct:    7 DPEELYVRQEKIGKGSFGEVFKGINKKTNETIAIKTIDLEDAEDEIEDIQQEINVLSQCESPFVTKYFGSFLKGS-KLWIIMEYLAGGSVLDLM-KPGPFDEGYIAIILRELLKGLEYLHSEGKIHRDIKAANVLLSASG-DVKLADFGVSGQLTDQMTKRNTFVGTPFWMAPE 177          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: MP2K6_HUMAN (Dual specificity mitogen-activated protein kinase kinase 6 OS=Homo sapiens GN=MAP2K6 PE=1 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 4.057e-20
Identity = 73/211 (34.60%), Postives = 110/211 (52.13%), Query Frame = 1

Query:  190 DLEKLQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRT-DSPFIVQCFGIFEKPSGDIAILMEYMDSGTLD----TLLNKNGTFSEPKLAHIASQILKGLSYLHGH-KIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPERFDPDXXXXXXXXXXXDIWSXXXXXXXXXXGHFPF 804
            DLE +  LG G  G V K++H  + +I A+K +    +   ++++  +++I  RT D PF V  +G   +  GD+ I ME MD+ +LD     +++K  T  E  L  IA  I+K L +LH    +IHRD+KPSN+L+N    QVK+ DFG+S  +  S+ A     G   YM+PER +P+           DIWS            FP+
Sbjct:   52 DLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR-EGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSV-AKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPY 257          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: STK4L_DICDI (Serine/threonine-protein kinase 4 homolog B OS=Dictyostelium discoideum GN=krsB PE=3 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 5.298e-20
Identity = 58/171 (33.92%), Postives = 101/171 (59.06%), Query Frame = 1

Query:  190 DLEKLQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRTDSPFIVQCFGIFEKPSGDIAILMEYMDSGTLDTLLN-KNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPE 699
            + + ++ LG G+ G+VYK  ++ T  I A+K+V  + D    +++ +E+ I+++  S ++VQ +G + K      I+MEY   G++  ++N  N   +E ++A +    LKGL YLH +  IHRDIKP N+LV+    + K+ADFGVS  +       N+ +GT  +++PE
Sbjct:   22 EFDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINED---FQEILKEINIMKQCKSKYVVQYYGNYFKDE-TCWIIMEYCAFGSVSDMMNITNRVLNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEG-ECKLADFGVSGQLSERTRKRNTVIGTPFFLAPE 187          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: MP2K6_MOUSE (Dual specificity mitogen-activated protein kinase kinase 6 OS=Mus musculus GN=Map2k6 PE=2 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 5.298e-20
Identity = 72/211 (34.12%), Postives = 110/211 (52.13%), Query Frame = 1

Query:  190 DLEKLQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRT-DSPFIVQCFGIFEKPSGDIAILMEYMDSGTLD----TLLNKNGTFSEPKLAHIASQILKGLSYLHGH-KIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPERFDPDXXXXXXXXXXXDIWSXXXXXXXXXXGHFPF 804
            DLE +  LG G  G V K++H  + +I A+K +    +   ++++  ++++  RT D PF V  +G   +  GD+ I ME MD+ +LD     +++K  T  E  L  IA  I+K L +LH    +IHRD+KPSN+L+N    QVK+ DFG+S  +  S+ A     G   YM+PER +P+           DIWS            FP+
Sbjct:   52 DLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFR-EGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLG-QVKMCDFGISGYLVDSV-AKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPY 257          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: MP2K6_BOVIN (Dual specificity mitogen-activated protein kinase kinase 6 OS=Bos taurus GN=MAP2K6 PE=2 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 5.298e-20
Identity = 73/211 (34.60%), Postives = 110/211 (52.13%), Query Frame = 1

Query:  190 DLEKLQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRRT-DSPFIVQCFGIFEKPSGDIAILMEYMDSGTLD----TLLNKNGTFSEPKLAHIASQILKGLSYLHGH-KIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPERFDPDXXXXXXXXXXXDIWSXXXXXXXXXXGHFPF 804
            DLE +  LG G  G V K++H  + +I A+K +    +   ++++  +++I  RT D PF V  +G   +  GD+ I ME MD+ +LD     +++K  T  E  L  IA  I+K L +LH    +IHRD+KPSN+L+N    QVK+ DFG+S  +  S+ A     G   YM+PER +P+           DIWS            FP+
Sbjct:   52 DLEPIVELGRGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFR-EGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSV-AKTIDAGCKPYMAPERINPE-LNQKGYSVKSDIWSLGITMIELAILRFPY 257          

BLAST of EY728674 vs. ExPASy Swiss-Prot
Match: MIG15_CAEEL (Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=1 SV=3)

HSP 1 Score: 98.5969 bits (244), Expect = 5.298e-20
Identity = 65/212 (30.66%), Postives = 116/212 (54.72%), Query Frame = 1

Query:  196 EKLQVLGHGNGGTVYKVQHRCTLKIYALKVVHGDADPTVRRQVFREMEILRR-TDSPFIVQCFGIFEK--PSG-----DIAILMEYMDSGTLDTLLN--KNGTFSEPKLAHIASQILKGLSYLHGHKIIHRDIKPSNLLVNNNNMQVKIADFGVSKIMCRSLDACNSYVGTCAYMSPERFDPDXXXXXXXXXXXDIWSXXXXXXXXXXGHFP 801
            E ++V+G+G  G VYK +H  T ++ A+K+++ + D     ++  E+ +L++ +    +   +G F K  PS       + ++ME+  SG++  L+   K G+  E  +A+I  +IL+GL +LH  K+IHRDIK  N+L+  ++ +VK+ DFGVS  + +++   N+++GT  +M+PE    D           D+WS          GH P
Sbjct:   22 ELIEVVGNGTYGQVYKGRHVKTAQLAAIKIMNINEDE--EDEIKLEINMLKKHSHHRNVATYYGAFIKKLPSSTGKHDQLWLVMEFCGSGSITDLVKNTKGGSLKEEWIAYICREILRGLYHLHQSKVIHRDIKGQNVLL-TDSAEVKLVDFGVSAQLDKTVGRRNTFIGTPYWMAPEVIACDESPEATYDSRSDLWSLGITALEMAEGHPP 230