EY702238

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: LYS12_SCHPO (Probable homoisocitrate dehydrogenase OS=Schizosaccharomyces pombe GN=lys12 PE=1 SV=1)

HSP 1 Score: 88.9669 bits (219), Expect = 1.492e-28
Identity = 68/217 (31.34%), Postives = 108/217 (49.77%), Query Frame = 1

Query:   61 ITATLFPGDGIGPEIAESVKQVFRTAEVPVEWEEHYVGTEIDP------RTQSFLTWESLESVRRN-KVGLKGPMATPIGK--GHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVNLITIRENTEGEYSGLEHQVV----RGVVESLKIITRQASLRVAEYAFHYAKT------------HGRERVSAIHKANIMQKTDGLFLKCCREVAEKYP 636
            I   L P DGIG E+  + +++     +P + +  +   ++D       RT   L   ++E ++      L G + +P  K  G+ S  + LRK++ LYANVRP  SL G K +   V+L+ +RENTE  Y   E  V     + V E+++ I+ +AS ++ + AF  AK+            H +  V+ IHK+N+M  TDGLF + CR      P
Sbjct:    7 IVLGLIPADGIGKEVVPAARRLMEN--LPAKHKLKFDFIDLDAGWGTFERTGKALPERTVERLKTECNAALFGAVQSPTHKVAGYSSPIVALRKKMGLYANVRPVKSLDGAKGK--PVDLVIVRENTECLYVKEERMVQNTPGKRVAEAIRRISEEASTKIGKMAFEIAKSRQKIRESGTYSIHKKPLVTIIHKSNVMSVTDGLFRESCRHAQSLDP 219          

HSP 2 Score: 58.9214 bits (141), Expect = 1.492e-28
Identity = 27/53 (50.94%), Postives = 35/53 (66.04%), Query Frame = 3

Query:  648 EEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCNNGE 806
            +E  +D+    L + P  FDV+V PNLYGDI+SD  A +IG LGL PS N G+
Sbjct:  227 DEQIVDSMVYRLFREPECFDVVVAPNLYGDILSDGAASLIGSLGLVPSANVGD 279          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: IDH_STRMU (Isocitrate dehydrogenase [NADP] OS=Streptococcus mutans GN=icd PE=3 SV=2)

HSP 1 Score: 94.7449 bits (234), Expect = 1.400e-26
Identity = 68/216 (31.48%), Postives = 108/216 (50.00%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTAEVPVE-------WEEHYVGTEIDPRTQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKT--RYDDVNLITI-RENTEGEYSGLEHQVVRGVVE-----------------------SLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEK 630
            GDG+G +I ++ + VF  A   V        W E   G +    T ++L  E+LE ++ + + +KGP+ TP+G G RSLN+ LR+EL+L+A VRP     G  +  ++ +   ITI RENTE  Y+G+E       V+                        +K I+ + S R+   A  YA  +   +V+ +HK NI + T+G F K   E+A++
Sbjct:   25 GDGVGQDIWKNAQIVFDKAIAKVYGGHKQVIWREVLAGKKAYNETGNWLPNETLEIIKTHLLAIKGPLETPVGGGIRSLNVALRQELDLFACVRPVRYFKGVPSPLKHPEKTAITIFRENTEDIYAGIEWNAGTAEVQKVINFLQDDMQVKKIRFPKSSSIGIKPISIEGSQRLIRAAIEYALANNLTKVTLVHKGNIQKFTEGGFRKWGYELAKR 240          

HSP 2 Score: 45.4394 bits (106), Expect = 1.400e-26
Identity = 18/50 (36.00%), Postives = 29/50 (58.00%), Query Frame = 3

Query:  648 EEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCN 797
            +++  DN    ++  P  FDV+ + NL GD  SD  A  +GG+G++P  N
Sbjct:  254 DDIIADNFLQQILLKPERFDVVALTNLNGDYASDALAAQVGGIGISPGAN 303          

HSP 3 Score: 21.1718 bits (43), Expect = 1.400e-26
Identity = 7/10 (70.00%), Postives = 9/10 (90.00%), Query Frame = 1

Query:  832 HGSTPDIAGK 861
            HG+ PDIAG+
Sbjct:  317 HGTAPDIAGQ 326          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: IDH_HELPY (Isocitrate dehydrogenase [NADP] OS=Helicobacter pylori GN=icd PE=3 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 1.715e-26
Identity = 68/225 (30.22%), Postives = 114/225 (50.67%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTA-------EVPVEWEEHYVGT----------EIDPRTQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPC--YSLPGYKTRYDDVNLITIRENTEGEYSGLEHQ--------VVRGVVESLKI---------------ITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEK 630
            GDGIG +I  ++ +V  +A       E  + W E +VG           E+ P  Q  L  +++E++   KV +KGP+ TPIG+G RSLN+ LR++++LY  +RP   Y  P        V+++  REN+E  Y+G+E Q        ++  +   LK+               I+++ + R+   A  YA  + +  V+ +HK NIM+ T+G F+K    +A+K
Sbjct:   37 GDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDYKELSPEEQWLLP-DTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVKKIRFPESSGIGVKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK 260          

HSP 2 Score: 40.817 bits (94), Expect = 1.715e-26
Identity = 17/50 (34.00%), Postives = 28/50 (56.00%), Query Frame = 3

Query:  648 EEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCN 797
            +++  D     ++  PS + V+   NL GD ISD  A ++GG+G+ P  N
Sbjct:  287 KDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGAN 336          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: IDH_HELPJ (Isocitrate dehydrogenase [NADP] OS=Helicobacter pylori J99 GN=icd PE=3 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 1.715e-26
Identity = 68/225 (30.22%), Postives = 114/225 (50.67%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTA-------EVPVEWEEHYVGT----------EIDPRTQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPC--YSLPGYKTRYDDVNLITIRENTEGEYSGLEHQ--------VVRGVVESLKI---------------ITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEK 630
            GDGIG +I  ++ +V  +A       E  + W E +VG           E+ P  Q  L  +++E++   KV +KGP+ TPIG+G RSLN+ LR++++LY  +RP   Y  P        V+++  REN+E  Y+G+E Q        ++  +   LK+               I+++ + R+   A  YA  + +  V+ +HK NIM+ T+G F+K    +A+K
Sbjct:   37 GDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEEQWLLP-DTIEAINHYKVSIKGPLTTPIGEGFRSLNVALRQKMDLYVCLRPVRWYGSPSPVKEPQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELKVEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYALAQK 260          

HSP 2 Score: 40.817 bits (94), Expect = 1.715e-26
Identity = 17/50 (34.00%), Postives = 28/50 (56.00%), Query Frame = 3

Query:  648 EEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCN 797
            +++  D     ++  PS + V+   NL GD ISD  A ++GG+G+ P  N
Sbjct:  287 KDMIADAFLQQILLRPSEYSVIATMNLNGDYISDALAAMVGGIGIAPGAN 336          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: IDH_COXBU (Isocitrate dehydrogenase [NADP] OS=Coxiella burnetii GN=icd PE=1 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 1.715e-26
Identity = 70/218 (32.11%), Postives = 111/218 (50.92%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTA-------EVPVEWEEHYVGTEIDP--RTQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRY---DDVNLITIRENTEGEYSGLEH--------------QVVRGVVE---------SLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEK 630
            GDGIG +IA  +K V   A       +  +EW E Y G +        ++L  E+LE+++  +V +KGP+ TP+G G RSLN+ LR++L+LY  +RP     G  +     + VN++  REN+E  Y+G+E               Q   GV +          +K ++++ + R+   A  YA  + R+ V+ +HK NIM+ T+G F     EVA K
Sbjct:   44 GDGIGIDIAPVMKNVVDAAVEKSYAGKRKIEWMEIYAGEKATKVYGKDNWLPDETLEAIKEYQVAIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFTGVPSPVKTPEKVNMVIFRENSEDIYAGIEWPAGSPEAVKLINFLQNEMGVKKIRFPETAGIGIKPVSKEGTSRLVRRAIQYAIDNDRDSVTLVHKGNIMKFTEGAFKDWGYEVAVK 261          

HSP 2 Score: 40.817 bits (94), Expect = 1.715e-26
Identity = 18/52 (34.62%), Postives = 28/52 (53.85%), Query Frame = 3

Query:  642 TYEEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCN 797
            T ++V  D     ++  P+ + V+   NL GD ISD  A  +GG+G+ P  N
Sbjct:  286 TIKDVIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAEVGGIGIAPGAN 337          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: DLPA_LEGPH (Protein dlpA OS=Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) GN=dlpA PE=3 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 1.404e-25
Identity = 60/229 (26.20%), Postives = 104/229 (45.41%), Query Frame = 1

Query:   58 PITATLFPGDGIGPEIAESVKQVFRTAEVPVEWEEHYVGTEIDPRTQSFL---TWESLESVRRNKVG---------LKGPMATPIGKG---HRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVNLITIRENTEGEYSGLEHQVVRGVVES-------------------LKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKYPEI 642
            PI   + PGDGIG E+ E+   VF   +VPV      +G E   +  + +   TW+ + S     +G          K  ++  + K    + S  + LR+ L+L+ANVRPC+S+      +   N   IREN+EG Y G ++  +   + S                   L++ ++    R+ ++AF +A   G  RV+   K N+++++     K     A++YP+I
Sbjct:    6 PIKIAVLPGDGIGIEVTEATLPVFEVLDVPVILNYGDIGWEFWKKEGAAIPSRTWQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSIDDQSKPF---NFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKI 231          

HSP 2 Score: 59.6918 bits (143), Expect = 1.404e-25
Identity = 26/51 (50.98%), Postives = 37/51 (72.55%), Query Frame = 3

Query:  660 IDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCNNGEGG 812
            +D   + L+K+P  F V+V  N++GDI+SD+ AGV+GGLGL PS N G+ G
Sbjct:  238 VDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKG 288          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: IDH1_COLMA (Isocitrate dehydrogenase [NADP] 1 OS=Colwellia maris GN=icdI PE=1 SV=2)

HSP 1 Score: 97.0561 bits (240), Expect = 1.840e-25
Identity = 61/208 (29.33%), Postives = 108/208 (51.92%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTA-------EVPVEWEEHYVGTEIDPR--TQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCY---SLPGYKTRYDDVNLITIRENTEGEYSGLEHQ--------VVRGVVE---------------SLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLF 600
            GDGIG ++   + +V   A       +  +EW E Y G +      ++++L  E+L  ++  KV +KGP+ TP+G G  SLN+ +R+ L+LY   RP      +P    R  +V+++  RENTE  Y+G+E++        V++ ++E                +K ++++ S R+   A  YA  + ++ V+ +HK NIM+ T+G F
Sbjct:   34 GDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETWLPEETLNILQEYKVSIKGPLTTPVGGGMSSLNVAIRQMLDLYVCQRPVQWFTGVPSPVKRPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAF 241          

HSP 2 Score: 40.4318 bits (93), Expect = 1.840e-25
Identity = 17/53 (32.08%), Postives = 29/53 (54.72%), Query Frame = 3

Query:  648 EEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCNNGE 806
            ++V  D     ++  P+ + V+   NL GD +SD  A  +GG+G+ P  N G+
Sbjct:  278 KDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSDALAAQVGGIGIAPGANLGD 330          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: LEU3_THEFY (3-isopropylmalate dehydrogenase OS=Thermobifida fusca (strain YX) GN=leuB PE=3 SV=1)

HSP 1 Score: 83.5741 bits (205), Expect = 1.845e-25
Identity = 60/212 (28.30%), Postives = 101/212 (47.64%), Query Frame = 1

Query:   61 ITATLFPGDGIGPEI-AESVKQVFRTAE---VPVEWEEHYVGTEIDPRTQSFLTWESLESVRRNK---VGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRY-----DDVNLITIRENTEGEYSGLEHQVVRGVVESL----KIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKYPEIHM 648
            +   + PGDGIGPE+ AE +K +   A    + ++  E+ +G +    T   L     E +R++    +G  G    P G   R L L LR   + Y N+RP    PG  T       +D++++ +RE TEG Y+G+   + +G    +     + TR    RV  YAF  A      +++ +HK N++     L+ +  REV  +YP++ +
Sbjct:    6 VKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYELGAQRWHATGEVLPDAVEEELRQHDAILLGAVGDPTVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPLAGVAPEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEV 217          

HSP 2 Score: 53.9138 bits (128), Expect = 1.845e-25
Identity = 30/67 (44.78%), Postives = 38/67 (56.72%), Query Frame = 3

Query:  627 EVP*DTYEEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCN-NGEGGLPCL 824
            E P    + + +D   M  V  P  FDV+V  NL+GDII+DL A V GG+GL  S N N EG  P +
Sbjct:  211 EYPQVEVDYLHVDAATMFFVTQPRRFDVVVTDNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSM 277          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: LEU3_COREF (3-isopropylmalate dehydrogenase OS=Corynebacterium efficiens GN=leuB PE=3 SV=2)

HSP 1 Score: 86.2705 bits (212), Expect = 2.404e-25
Identity = 60/198 (30.30%), Postives = 94/198 (47.47%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTAEVPVEWEEHYVGTEIDPRTQSFLTWESLESVRRNKVGLKG----PMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKT---RYDDVNLITIRENTEGEYSGLEHQVVRG----VVESLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKYPEI 642
            GDGIGPE+ +   +V R     +E  +  +G     R    LT E L  +R +   L G    P + P G   R L L LR  L+ + N+RP     G ++      +++ + +RE TEG Y+G    +  G          + TR  + RV  YAF  A++  R  ++ +HK N++    GL+ +   EVA +YPE+
Sbjct:    8 GDGIGPEVTDEALKVLRALRADIETTDLDLGARRYLRNGELLTDEDLALLREHDAILLGAIGAPGSVPPGVLERGLLLKLRFALDHHVNLRPSKLYEGVESPLKNPGEIDFVVVREGTEGAYTGNGGAIRVGTPHETANETSVNTRYGAERVIRYAFELAQSR-RRHLTLVHKTNVLVHGGGLWQRTVDEVAREYPEV 204          

HSP 2 Score: 50.8322 bits (120), Expect = 2.404e-25
Identity = 26/58 (44.83%), Postives = 35/58 (60.34%), Query Frame = 3

Query:  624 REVP*DTYEEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCN 797
            RE P  T +   ID   + LV +PS FDV+V  NL+GDI++D    + GG+GL  S N
Sbjct:  199 REYPEVTVDYNHIDAATIYLVTDPSRFDVIVTDNLFGDILTDEAGAISGGIGLAASGN 256          

BLAST of EY702238 vs. ExPASy Swiss-Prot
Match: LEU3_LACLA (3-isopropylmalate dehydrogenase OS=Lactococcus lactis subsp. lactis GN=leuB PE=3 SV=3)

HSP 1 Score: 74.3294 bits (181), Expect = 5.298e-25
Identity = 59/209 (28.23%), Postives = 98/209 (46.89%), Query Frame = 1

Query:   82 GDGIGPEIAESVKQVFRTAEVPVEWE-----EHYVGTEIDPRTQSFLTWESLESVRRNKVGLKGPMATPIGKGHRSLN----------LTLRKELNLYANVRPCYSLPGYK-----TRYDDVNLITIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKYPEIHM 648
            GDGIGPEI  +   V +     +++E     + + G  ID      L  E+L++V+     L   +      GH   N          L LRKEL LYANVRP    P  K        ++V+ + IRE T G Y G +H++       +   +     R+  +AF  A++  R+ ++++ K N++  T  L+ K   E+A++YP++ +
Sbjct:   10 GDGIGPEIMSAGLSVLKAVSKKIDFEYELEAKDFGGIAIDKHGHP-LPEETLQAVKNADAILLAAI------GHPKYNNAKVRPEQGLLALRKELGLYANVRPLKIYPALKKLSPIRNVENVDFLVIRELTGGIYFG-QHELADDKARDVNDYSADEIRRILHFAFKSAQSRPRKLLTSVDKQNVL-ATSKLWRKMADEIADEYPDVRL 209          

HSP 2 Score: 61.6178 bits (148), Expect = 5.298e-25
Identity = 28/63 (44.44%), Postives = 40/63 (63.49%), Query Frame = 3

Query:  627 EVP*DTYEEVXIDNCCMMLVKNPSAFDVLVMPNLYGDIISDLCAGVIGGLGLTPSCNNGEGGL 815
            E P    E   +D+C M+L+ NP  FDV+V  NL+GDI+SD  + + G LG+ PS ++G  GL
Sbjct:  203 EYPDVRLEHQLVDSCAMLLITNPQQFDVIVTENLFGDILSDEASSLAGSLGVMPSSSHGFNGL 265