FC871273

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: DLK1_CAEBR (Mitogen-activated protein kinase kinase kinase dlk-1 OS=Caenorhabditis briggsae GN=dlk-1 PE=3 SV=1)

HSP 1 Score: 109.383 bits (272), Expect = 2.306e-23
Identity = 67/212 (31.60%), Postives = 104/212 (49.06%), Query Frame = 3

Query:   33 EVNMMSRVKHDNLVKFLGAC-KDPLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXX-YRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQI 662
            E+  +  ++H N+++FLG C K P   IV E  P   L   L   + N +   +  ++  +IA  M  LH N +IHRDLK  N+L++ +  S+K+ DFG +                  WMAPE+         +K+  N KVDVYSFG+VLWE+LT   P+  ++ +   +          +PE+    L  +++ C  +    RPSFS I
Sbjct:   98 EIKHLRHLRHKNIIEFLGVCSKSPCYCIVMEYCPKGQLCTVL--RQKNLITRQMFSDWVKEIADGMHYLHQNKVIHRDLKSPNILISAED-SIKICDFGTSHLQKKNDSTMMSFCGTVSWMAPEMI--------KKEPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILNLPMPEEAPRGLVLLIKQCLSQKGRNRPSFSHI 298          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: Y0133_DICDI (Probable serine/threonine-protein kinase DDB_G0278665 OS=Dictyostelium discoideum GN=DDB_G0278665 PE=3 SV=1)

HSP 1 Score: 108.997 bits (271), Expect = 3.012e-23
Identity = 80/244 (32.79%), Postives = 123/244 (50.41%), Query Frame = 3

Query:   24 FIREVNMMSRV-KHDNLVKFLGACKDPLMVIVTELLPGMSLRKYLVSLRPN-KLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLL---LTPDQK-SLKLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKH--ARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIRMLNAFLFTLRPPSPSVPESDT 731
            F +E+ M   +  H N+V F+G C  P   +V E + G SL KYL +  PN      + L  A DIA+ M  LH N I+H DLKP N L   ++P+   S+KLADFGLA               + +M+PE+++        +K ++   DV+S+G  L E+LTN+ P++    L     A  +     P +P +I  DL  I+++C+  D   RP+F  I + L+A   +L     S+  S +
Sbjct:  230 FEKELEMHKELLHHPNIVHFVGFCVSP-KCLVLEYIEGGSLDKYLHN--PNYTFSPQLRLKMANDIAKGMCFLHRNEILHLDLKPQNFLVVSISPEAPVSIKLADFGLATSSSRSFYGPTVEGSFLYMSPEVFT--------QKKFSRAADVWSYGACLIEILTNKRPYQEYDQLGYLELARVREEGLPPMIPPEIEGDLRKIIEACFHRDHTKRPNFENIEQFLDAMTDSLFNVQSSIDSSSS 462          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: LRK1_CAEEL (Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6)

HSP 1 Score: 108.612 bits (270), Expect = 3.934e-23
Identity = 82/235 (34.89%), Postives = 125/235 (53.19%), Query Frame = 3

Query:   30 REVNMMSRVKHDNLVKFLGACKDPLMVIVTELLPGMSLRKYLVSLRP--NKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLL-------LTPDQKSL-KLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPG-LPEDI---SPDLAFIVQSCWVEDPNLRPSFSQIIRMLNAFLFT 692
            +E++++SR+KH N++  +G C  PL ++V EL P  +L + L S R    KL L V    A+ +ARA++ LH+  II+RDLK +N+L        +P    L KL D+G++R                +MAPE+     +R   ++ Y  KVD +SFG+ L+ELLT + PFE   +++         ARP  LP ++   +P L  +V  CW   P  RPS SQ++    A  FT
Sbjct: 1769 QELSLLSRMKHPNVIGLVGVCTFPLSLVV-ELAPLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEI-----VRFNGEEEYTQKVDCFSFGMFLYELLTLKFPFESEEHVK---ERMLDGARPVLLPHELLLPTPMLDLLVH-CWSAHPESRPSSSQLVGFCAAPEFT 1993          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: DRKA_DICDI (Probable serine/threonine-protein kinase drkA OS=Dictyostelium discoideum GN=drkA PE=3 SV=1)

HSP 1 Score: 108.612 bits (270), Expect = 3.934e-23
Identity = 71/222 (31.98%), Postives = 115/222 (51.80%), Query Frame = 3

Query:   24 FIREVNMMSRVKHDNLVKFLGACK-DPLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANG--IIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIRMLNA 680
            F RE+N+M  ++H N+++FLG+C   P + I TE +P  SL   L   +  +L   + +   +D A+ +  LH +   I+HRDLK  NLL+  + K +K+ADFGL+                 W +PE+  +        + Y  K DVYSFGI+LWE  T + P+ G+   Q  +A   +  RP +P++  P    ++  C  E+P+ RP+  Q +  L +
Sbjct:  416 FHREINLMKNLRHPNVIQFLGSCLIPPDICICTEYMPRGSLYSILHD-QALQLQWSLLIKMMIDAAKGVIYLHNSTPVILHRDLKSHNLLVDENWK-VKVADFGLSTIEQQGATMTACGTPC-WTSPEVLRS--------QRYTEKADVYSFGIILWECATRQDPYFGIPPFQVIFAVGREGMRPPVPQNGPPKYIQLLIDCLNENPSHRPTMEQCLERLES 626          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: DLK1_CAEEL (Mitogen-activated protein kinase kinase kinase dlk-1 OS=Caenorhabditis elegans GN=dlk-1 PE=1 SV=4)

HSP 1 Score: 107.842 bits (268), Expect = 6.711e-23
Identity = 67/212 (31.60%), Postives = 102/212 (48.11%), Query Frame = 3

Query:   33 EVNMMSRVKHDNLVKFLGAC-KDPLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXX-YRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQI 662
            E+  +  ++H N+++FLG C K P   IV E      L   L S   N +   +   +  +IA  M  LH N +IHRDLK  N+L++ +  S+K+ DFG +                  WMAPE+         +K+  N KVDVYSFG+VLWE+LT   P+  ++ +   +          +PE+    L  +++ C  +    RPSFS I
Sbjct:  171 EIKHLRHLRHQNIIEFLGVCSKSPCYCIVMEYCSKGQLCTVLKSR--NTITRELFAQWVKEIADGMHYLHQNKVIHRDLKSPNILISAED-SIKICDFGTSHMQKKMDSTMMSFCGTVSWMAPEMI--------KKQPCNEKVDVYSFGVVLWEMLTRETPYANIAQMAIIFGVGTNILSLPMPEEAPKGLVLLIKQCLSQKGRNRPSFSHI 371          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: TXK_HUMAN (Tyrosine-protein kinase TXK OS=Homo sapiens GN=TXK PE=1 SV=3)

HSP 1 Score: 107.457 bits (267), Expect = 8.764e-23
Identity = 74/228 (32.46%), Postives = 116/228 (50.88%), Query Frame = 3

Query:    6 ALLEDRFIREVNMMSRVKHDNLVKFLGAC--KDPLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXXY--RWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLT-NRLPFEGMSNLQA--AYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIR 668
            ++ E+ FI E  +M ++ H  LV+  G C  + PL  IVTE +    L  YL   +  KL   + L+   DI   M+ L  NG IHRDL   N L++     +K++DFG+ R              +  +W  PE++            Y++K DV+SFG+++WE+ T  ++PFE  SNLQ   A +  F+  RP L       +  ++ SCW E P  RP+F++++R
Sbjct:  305 SMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLY-IVTEFMENGCLLNYLRENK-GKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-STCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLF--------NKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHL---APMSIYEVMYSCWHEKPEGRPTFAELLR 518          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: M3K12_RAT (Mitogen-activated protein kinase kinase kinase 12 OS=Rattus norvegicus GN=Map3k12 PE=1 SV=1)

HSP 1 Score: 107.457 bits (267), Expect = 8.764e-23
Identity = 65/216 (30.09%), Postives = 106/216 (49.07%), Query Frame = 3

Query:   33 EVNMMSRVKHDNLVKFLGACKD-PLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIRMLN 677
            ++  + ++KH N++ F G C   P   I+ E      L + L + RP    L V  ++++ IA  M+ LH + IIHRDLK  N+L+T D   +K++DFG ++                WMAPE+           +  + KVD++SFG+VLWELLT  +P++ + +    +          +P         +++ CW   P  RPSF QI+  L+
Sbjct:  194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLV--DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDV-VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI--------RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRPSFRQILLHLD 398          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: M3K12_MOUSE (Mitogen-activated protein kinase kinase kinase 12 OS=Mus musculus GN=Map3k12 PE=1 SV=1)

HSP 1 Score: 107.457 bits (267), Expect = 8.764e-23
Identity = 65/216 (30.09%), Postives = 106/216 (49.07%), Query Frame = 3

Query:   33 EVNMMSRVKHDNLVKFLGACKD-PLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIRMLN 677
            ++  + ++KH N++ F G C   P   I+ E      L + L + RP    L V  ++++ IA  M+ LH + IIHRDLK  N+L+T D   +K++DFG ++                WMAPE+           +  + KVD++SFG+VLWELLT  +P++ + +    +          +P         +++ CW   P  RPSF QI+  L+
Sbjct:  194 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLV--DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDV-VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI--------RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 398          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: M3K12_HUMAN (Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2)

HSP 1 Score: 107.457 bits (267), Expect = 8.764e-23
Identity = 65/216 (30.09%), Postives = 106/216 (49.07%), Query Frame = 3

Query:   33 EVNMMSRVKHDNLVKFLGACKD-PLMVIVTELLPGMSLRKYLVSLRPNKLDLHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIRMLN 677
            ++  + ++KH N++ F G C   P   I+ E      L + L + RP    L V  ++++ IA  M+ LH + IIHRDLK  N+L+T D   +K++DFG ++                WMAPE+           +  + KVD++SFG+VLWELLT  +P++ + +    +          +P         +++ CW   P  RPSF QI+  L+
Sbjct:  161 DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLV--DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDV-VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI--------RNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLD 365          

BLAST of FC871273 vs. ExPASy Swiss-Prot
Match: Y1197_DICDI (Probable serine/threonine-protein kinase DDB_G0288147 OS=Dictyostelium discoideum GN=DDB_G0288147 PE=3 SV=1)

HSP 1 Score: 106.686 bits (265), Expect = 1.495e-22
Identity = 68/234 (29.06%), Postives = 125/234 (53.42%), Query Frame = 3

Query:   24 FIREVNMMSRVKHDNLVKFLGA----CKDPLMVIVTELLPGMSLRKYLVSLRPNKLD---LHVALNFALDIARAMDCLHANGIIHRDLKPDNLLLTPDQKSLKLADFGLARXXXXXXXXXXXXXXYRWMAPELYSTVTLRQGEKKHYNNKVDVYSFGIVLWELLTNRLPFEGMSNLQAAYAAAFKHARPGLPEDISPDLAFIVQSCWVEDPNLRPSFSQIIRMLNAFLFTLRPP 704
            F +E+ ++S  +H  ++K  GA       P   IVTEL    ++   L  +R        + + ++ A+D A++++ +H+  IIHRD+K +N L+  + + +KL DFG++R                +MA EL++         + Y+   DV+SFG+VLWE+ T   P++ ++ ++ A        RP +P  +   +A +++SCWV+ P+LRP+F++I+++   F   L PP
Sbjct:  640 FYKEITIVSASQHPKVIKCYGAHTKNTNKPF--IVTELCSRGTISNALNQIRKTTGQPPAIPLIVHMAIDAAQSLEFIHSKNIIHRDVKGNNFLVNENWE-VKLIDFGVSRFVEARLGYTIVGTP-NYMACELFNG--------QPYHQPADVFSFGVVLWEMFTQDTPYKNLTRIEQALFVQ-SGGRPTIPPTVPTTIANLIESCWVQTPHLRPTFTEILKV---FYSLLTPP 857