EY655338

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: IRE1_YEAST (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Saccharomyces cerevisiae GN=IRE1 PE=1 SV=2)

HSP 1 Score: 153.68 bits (387), Expect = 1.432e-36
Identity = 101/315 (32.06%), Postives = 152/315 (48.25%), Query Frame = 1

Query:   13 GSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAK-----------LSDMGISRRLLGDMSSLGHHATG-CGSSGWQAPEQLLHG-------------------------------RQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHITKERVDLFLXGC------IPEAXDLISRXVNPD 810
            GS+GTVV++G ++GRPVAVKR++    D+A  EI+ L  SD HPN++R+Y  E    F+Y++LE C  +L DL+++ + S        D+  +   EY                           +SL+R + SG+ HLH L IIHRDLKPQN+L+       A            +SD G+ ++L    SS   +     G+SGW+APE L                                  R TR++D+FS+ CV ++ ++ G+HPFGD+  R+ +I +    L    C      I EA DLIS+ ++ D
Sbjct:  683 GSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVS--------DENLKLQKEYN-------------------------PISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHD 964          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: IREA_DICDI (Probable serine/threonine-protein kinase ireA OS=Dictyostelium discoideum GN=ireA PE=3 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 2.700e-35
Identity = 103/296 (34.80%), Postives = 157/296 (53.04%), Query Frame = 1

Query:   13 GSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQ---TYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHG--RQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHITKERVDLFLXGCIPEAXDLISRXV--NPDLH*DMCVGRLHHLCFEV*ERLSF 879
            GS GT+VYEG  EGR VAVKR++      A +E+  LI SD+H N+VR+Y  E D +F+YL++  C  SLD  +Q   +   S  +S   +              ++ ++II + +              ++ +L  GL HLH L I+HRD+KP NVLI     +  K+SDMG+ + L  D  SL   +    S GWQ P + L+G  R T+ VD+FSL CV+++ +TG  HPFG R  R+ ++ K + D+     +P+   L+   +   P+   D+     H   +EV ++LSF
Sbjct:  584 GSCGTIVYEGKMEGRKVAVKRMLSQFVKFADREVSILIHSDEHTNVVRYYAKEEDDEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKTK------------QMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRV--KISDMGLGKLLDNDDQSLTFTS---DSHGWQ-PAEYLNGTNRNTKKVDIFSLGCVVYYLLTGA-HPFGHRYNREKNVLKGKFDIDQIKHLPDIHQLVHSMIQFEPEKRPDIGECINHPFFWEVHKKLSF 860          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: IRE1_CAEEL (Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=2 SV=2)

HSP 1 Score: 147.132 bits (370), Expect = 1.340e-34
Identity = 102/300 (34.00%), Postives = 149/300 (49.67%), Query Frame = 1

Query:   13 GSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLII---KERSLCAKLSDMGISRRLLGDMSSLGHH-ATG-CGSSGWQAPEQLLHGRQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHITKERVDLFLXGCIPE---AXDLISRXVNPD-LH*DMCVGRLHHLCFEV*E-RLSFF 882
            G  GTVVY G ++GR VAVKR+V      A +E   L  SD HP+++R++ +E+D  F YL+LE C+ SL+D                       +E K    +V + +RD                +M+    GL HLH   I+HRD+KPQNVLI    +   + A +SD G+ +R+    +S+    A+G  G+ GW APE L+    +  VD+FSL C+ ++ +T G HPFG  L R  +I      L     + +   A DLIS  +N + LH       L+H  F   E RL++F
Sbjct:  527 GCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRYLALELCIASLND----------------------YVEQKEVQQNVTIALRD----------------IMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQANIVNGEYTLNKLADLDDWSLADDLISSMLNVEPLHRLTADAVLNHPFFWTSEKRLAYF 788          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: PPK4_SCHPO (Serine/threonine-protein kinase ppk4 OS=Schizosaccharomyces pombe GN=ppk4 PE=2 SV=1)

HSP 1 Score: 144.821 bits (364), Expect = 6.651e-34
Identity = 92/268 (34.33%), Postives = 139/268 (51.87%), Query Frame = 1

Query:   13 GSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS-------LCAKLSDMGISRRLLGDMSSLGHHA-TGCGSSGWQAPEQLLHG-------------------RQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHITK 735
            GS+GT+VY G+YE R VAVKR++   +D+A +EI  L  SD HPNIVR+Y  +    F+Y+ +E C C+L DLI+                              K I  D  L+K+       L+SL+  +  G+ HLH L ++HRDLKPQN+L++   S       + A +SD G+S++L  + SSL +      GS GW++PE +L G                   + + A D+F+L C+ ++ +TGG HPFG   + + +I K
Sbjct:  663 GSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFLYIVIELCKCNLSDLIE------------------------------KPIAYD-DLFKSID-----LVSLLYQIAFGVSHLHSLDLVHRDLKPQNILLVVNNSPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGWRSPE-ILSGSLSQQSKEIQVKTREGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILK 893          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: IRLD_DICDI (Probable serine/threonine-protein kinase irlD OS=Dictyostelium discoideum GN=irlD PE=3 SV=1)

HSP 1 Score: 142.895 bits (359), Expect = 2.528e-33
Identity = 96/272 (35.29%), Postives = 149/272 (54.78%), Query Frame = 1

Query:   10 RGSNGTVVYEGIYEGR-PVAVKRLVRALHDVAFKEIQNLIA--SDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSD----SSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHGRQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHITKERVDLFLXGCIPEAXDLISRXVN 804
            RGSNGT+V++GI+  R PVA+K++ +A + +  KEI+ LI   +    NIVR+   E D  FVYL L  C  SL +L++   +    S+ N+    +   +  I  +LRL                       L L++D+V G+  LH+ GI+H DL P+N+LI  +R +   +SD+G+S+  +    S   HA   G  G+   E LL  R+T++VD+FS+ C+LF+ +TGGQHPFGD+  R  +I  ++  L        A DLIS+ ++
Sbjct: 1062 RGSNGTLVFKGIWNDRIPVAIKQMHKAFNPLISKEIEVLITLTNKNCNNIVRYIDQEEDDMFVYLGLTLCNGSLQNLVEKDLEINLISTSNNENNNNNKLKNFIGSELRL-----------------------LELIKDIVYGIQFLHQQGIVHNDLNPRNILIKDDRFI---ISDLGLSKMEVTSSYSFTMHAP-TGQEGFHPAEVLLEKRKTKSVDIFSMGCILFYLMTGGQHPFGDKFFRMANILTDKPILEPLKHNLVACDLISQMIS 1306          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: ERN2_MOUSE (Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Mus musculus GN=Ern2 PE=2 SV=1)

HSP 1 Score: 141.354 bits (355), Expect = 7.354e-33
Identity = 87/245 (35.51%), Postives = 125/245 (51.02%), Query Frame = 1

Query:   10 RGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSL---CAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPE--QLLHGRQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHI 729
            RG+ GT V+ G +EGR VAVKRL+R    +  +E+Q L  SD+HPN++R++  E+   F Y++LE C  SL + +++                                  DL  W     P+ +L  +M    SGL HLH L I+HRDLKP N+L+    S       +SD G+ ++L     S   H+   G+ GW APE  QL     T AVD+FS  CV ++ ++GG HPFG+ L R  +I
Sbjct:  516 RGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVES---------------------------------PDLDRWGL--EPTTVLQQMM----SGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTNAVDIFSAGCVFYYVLSGGSHPFGESLYRQANI 721          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: IRLC_DICDI (Probable serine/threonine-protein kinase irlC OS=Dictyostelium discoideum GN=irlC PE=3 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 1.254e-32
Identity = 94/268 (35.07%), Postives = 147/268 (54.85%), Query Frame = 1

Query:   10 RGSNGTVVYEGIYEGR-PVAVKRLVRALHDVAFKEIQNLIASDQHP--NIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHGRQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHITKERVDLFLXGCIPEAXDLISRXVN 804
            RGSNGT+V++GI+  R PVA+K++ +  + +  KEI+ LI        NIVR+   E D+  VYL L  C  SL +L++   ++   + F         + Y +   S           K N      LL L++D+V G+  LH+ GI+H DL P+N+LI  +R +   +SD+G+S+  +    S   HA   G  G+   E LL  R+T++VD+FS+ C+LF+ +TGGQHPFGD+  R ++I  ++  L        A DLIS+ ++
Sbjct:  989 RGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIEVLITLTNKNCYNIVRYIDQEEDESCVYLGLTLCDGSLQNLVEKGDNNLTLTQF---------LGYDINSSS-----------KNNSR----LLELIKDIVYGIQFLHQQGIVHNDLNPRNILIKDDRFI---ISDLGLSKMEVTSSYSFTMHAP-TGQEGFHPAEVLLEKRKTKSVDIFSMGCILFYLMTGGQHPFGDKFYRIVNILTDKPILEPLKHNLVACDLISQMIS 1228          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: ERN2_HUMAN (Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Homo sapiens GN=ERN2 PE=1 SV=2)

HSP 1 Score: 139.813 bits (351), Expect = 2.140e-32
Identity = 88/246 (35.77%), Postives = 125/246 (50.81%), Query Frame = 1

Query:   10 RGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSL---CAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPE--QLL-HGRQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHI 729
            RG+ GT V+ G +EGR VAVKRL+R    +  +E+Q L  SD+HPN++R++  E    F Y++LE C  SL + ++                 R  +E ++                           +++ L+SGL HLH L I+HRDLKP N+LI    S       LSD G+ ++L     S   H+   G+ GW APE  QLL     T AVD+FS  CV ++ ++GG HPFGD L R  +I
Sbjct:  528 RGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVE------------NPDLDRGGLEPEV---------------------------VLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANI 734          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: ERN1_HUMAN (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2)

HSP 1 Score: 137.117 bits (344), Expect = 1.387e-31
Identity = 78/245 (31.84%), Postives = 120/245 (48.98%), Query Frame = 1

Query:   13 GSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS---LCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHG---RQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHI 729
            G+ GT+VY G+++ R VAVKR++      A +E+Q L  SD+HPN++R++  E D+ F Y+++E C  +L + ++                                        K   H     ++L++   SGL HLH L I+HRDLKP N+LI    +   + A +SD G+ ++L     S    +   G+ GW APE L        T  VD+FS  CV ++ I+ G HPFG  L+R  +I
Sbjct:  580 GAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------------------------------KDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANI 785          

BLAST of EY655338 vs. ExPASy Swiss-Prot
Match: ERN1_MOUSE (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Mus musculus GN=Ern1 PE=2 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 2.366e-31
Identity = 77/245 (31.43%), Postives = 120/245 (48.98%), Query Frame = 1

Query:   13 GSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS---LCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQL---LHGRQTRAVDLFSLSCVLFFCITGGQHPFGDRLERDIHI 729
            G+ GT+VY+G+++ R VAVKR++      A +E+Q L  SD+HPN++R++  E D+ F Y+++E C  +L + ++                                        K   H     ++L+    SGL HLH L I+HRDLKP N+L+    +   + A +SD G+ ++L     S    +   G+ GW APE L        T  VD+FS  CV ++ I+ G HPFG  L+R  +I
Sbjct:  580 GAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------------------------------KDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANI 785