EY650458

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPCL1_MOUSE (Niemann-Pick C1-like protein 1 OS=Mus musculus GN=Npc1l1 PE=2 SV=1)

HSP 1 Score: 155.221 bits (391), Expect = 4.740e-37
Identity = 90/236 (38.14%), Postives = 126/236 (53.39%), Query Frame = 3

Query:   18 LSTRIEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYF-VVKDYNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTCFRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPLNKQXDLCNSLRAARXVSSRMSDTLK 722
            L   I  GL+Q + LP+DSYL  YF     YL VGPP+YF     YN+S+E+   N +CS + C+S SL  +I  AS  P  SY+A  A+SW+DDF+ W +P +  CCR +  G +                        +C     +  L   RP+TEQF + LPWFLN  P+  C KGG  AY TSV+L+    G I AS+F  +H PL    D   +LRA+R +++ ++  L+
Sbjct:  863 LMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEA-GMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSS-SCCRIYTRGPHKDEFCPS------------TDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLS--SDGQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELR 1082          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPCL1_RAT (Niemann-Pick C1-like protein 1 OS=Rattus norvegicus GN=Npc1l1 PE=1 SV=1)

HSP 1 Score: 154.066 bits (388), Expect = 1.056e-36
Identity = 89/236 (37.71%), Postives = 127/236 (53.81%), Query Frame = 3

Query:   18 LSTRIEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFV-VKDYNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTCFRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPLNKQXDLCNSLRAARXVSSRMSDTLK 722
            L   I  GL+Q++ LP+DSYL  YF     YL VGPP+YFV    +N+SSE+   N  CS + C S SL  +I  AS  P+ SY+A  A+SW+DDF+ W +P +  CCR ++ G +                        +C     +  L   RP+ EQF + LPWFLN  P+  C KGG  AY TSV+L+    G + AS+F  +H PL    D   +LRA+R +++ ++  L+
Sbjct:  863 LMCNINVGLDQELALPKDSYLIDYFLFLNRYLEVGPPVYFVTTSGFNFSSEA-GMNATCSSAGCKSFSLTQKIQYASEFPDQSYVAIAASSWVDDFIDWLTPSS-SCCRLYIRGPHKDEFCPS------------TDTSFNCLKNCMNRTLGPVRPTAEQFHKYLPWFLNDPPNIRCPKGGLAAYRTSVNLS--SDGQVIASQFMAYHKPLRNSQDFTEALRASRLLAANITADLR 1082          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPCL1_HUMAN (Niemann-Pick C1-like protein 1 OS=Homo sapiens GN=NPC1L1 PE=2 SV=1)

HSP 1 Score: 144.05 bits (362), Expect = 1.093e-33
Identity = 92/257 (35.80%), Postives = 129/257 (50.19%), Query Frame = 3

Query:   30 IEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFVVK-DYNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTCFRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNG---------------YESGII----------QASEFRTFHTPLNKQXDLCNSLRAARXVSSRMSDTLK 722
            I  GL+Q++ LP+DSYL  YF     Y  VG P+YFV    YN+SSE+   N +CS + C++ S   +I  A+  PE SY+A PA+SW+DDF+ W +P +  CCR +++G                    VN +  +C        + + RPS EQF + LPWFLN  P+  C KGG  AYSTSV+L                   SG I           AS F  +H PL    D   +LRAAR +++ ++  L+
Sbjct:  867 ISVGLDQELALPKDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAG-MNAICSSAGCNNFSFTQKIQYATEFPEQSYLAIPASSWVDDFIDWLTPSS--CCRLYISG----------PNKDKFCPSTVNSL--NCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAHCNLYLLDSASRFMAYHKPLKNSQDYTEALRAARELAANITADLR 1108          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPC1_PIG (Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1)

HSP 1 Score: 139.043 bits (349), Expect = 3.515e-32
Identity = 79/237 (33.33%), Postives = 129/237 (54.43%), Query Frame = 3

Query:   12 IALSTRIEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFVVKD-YNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTCFRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPLNKQXDLCNSLRAARXVSSRMSDTL 719
            IA+  ++E GL+Q + +P DSY+  YF + + YL  GPP+YFVV++ +NY+S  +  N +C    C+++SL+ +I  A+ +   + I    +SW+DD+  W  P++  CCR + N T                    + V   C  C   +     RP  E FM  LP FL+  P+  C KGGH AYS++V++ G  SG + A+ F T+HT L    D  ++++ AR ++S ++ T+
Sbjct:  850 IAVLNKVEIGLDQSLSMPDDSYVMDYFQSLSRYLHAGPPVYFVVEEGHNYTS-LKGQNMVCGGLGCNNDSLVQQIFTAAQLDNYTRIGFAPSSWIDDYFDWIKPQS-SCCRVY-NST--------------DQFCNASVVDPTCIRCRPLTSEGKQRPQGEDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILGNGSG-VGATYFMTYHTVLQASADFIDAMQKARLIASNITRTM 1068          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPC1_MOUSE (Niemann-Pick C1 protein OS=Mus musculus GN=Npc1 PE=1 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 2.278e-31
Identity = 74/238 (31.09%), Postives = 132/238 (55.46%), Query Frame = 3

Query:   12 IALSTRIEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFVVKD-YNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTCFRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPLNKQXDLCNSLRAARXVSSRMSDTLK 722
            +A+  +++ GL+Q + +P DSY+   F +  +YL  GPP+YFV+++ YNYSS  +  N +C    CD++SL+ +I  A+ +   + +    +SW+DD+  W SP++  CCR + N T+                   + +   C  C   +     RP  ++FM+ LP FL+  P+  C KGGH AY ++V++ G +   I A+ F T+HT L    D  ++++ AR ++S +++T++
Sbjct:  851 VAVVNKVDIGLDQSLSMPNDSYVIANFKSLAQYLHSGPPVYFVLEEGYNYSSR-KGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWIDDYFDWVSPQS-SCCRLY-NVTH--------------QFCNASVMDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPNPKCGKGGHAAYGSAVNIVG-DDTYIGATYFMTYHTILKTSADYTDAMKKARLIASNITETMR 1070          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPC1_HUMAN (Niemann-Pick C1 protein OS=Homo sapiens GN=NPC1 PE=1 SV=2)

HSP 1 Score: 132.109 bits (331), Expect = 4.297e-30
Identity = 70/236 (29.66%), Postives = 122/236 (51.69%), Query Frame = 3

Query:   12 IALSTRIEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFVVKDYNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTCFRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPLNKQXDLCNSLRAARXVSSRMSDTL 719
            IA+  +++ GL+Q + +P DSY+  YF + ++YL  GPP+YFV+++ +  + S+  N +C    C+++SL+ +I  A+ +   + I    +SW+DD+  W  P++  CCR                          + V   C  C   +     RP    FM  LP FL+  P+  C KGGH AYS++V++       + A+ F T+HT L    D  ++L+ AR ++S +++T+
Sbjct:  850 IAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQS-SCCR---------------VDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETM 1069          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPC1_YEAST (Niemann-Pick type C-related protein 1 OS=Saccharomyces cerevisiae GN=NCR1 PE=1 SV=1)

HSP 1 Score: 108.227 bits (269), Expect = 6.644e-23
Identity = 72/233 (30.90%), Postives = 106/233 (45.49%), Query Frame = 3

Query:   30 IEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFVVKDYNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVC------KDCTTCFRHSDLVNNR---PSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPLNKQXDLCNSLRAARXVSS 701
            I+ GL+Q + +P+DSYL  YF +   +L VGPP+Y VVK+ + +            + C+ +SL N + +       S I +P A+WLDD+ ++ +P+   CCR                        G + VC      + C TCF+      N    P  + FME L  ++NA PS  C  GG   YST++    Y    + AS FRT H PL  Q D   +      +SS
Sbjct:  770 IQFGLDQTLAVPQDSYLVDYFKDVYSFLNVGPPVYMVVKNLDLTKRQNQQKICGKFTTCERDSLANVLEQER---HRSTITEPLANWLDDYFMFLNPQNDQCCR---------------------LKKGTDEVCPPSFPSRRCETCFQQGSWNYNMSGFPEGKDFMEYLSIWINA-PSDPCPLGGRAPYSTAL---VYNETSVSASVFRTAHHPLRSQKDFIQAYSDGVRISS 974          

BLAST of EY650458 vs. ExPASy Swiss-Prot
Match: NPC1_CAEEL (Niemann-Pick C1 protein homolog 1 OS=Caenorhabditis elegans GN=ncr-1 PE=1 SV=2)

HSP 1 Score: 94.3597 bits (233), Expect = 9.928e-19
Identity = 63/247 (25.51%), Postives = 108/247 (43.72%), Query Frame = 3

Query:   12 IALSTRIEAGLEQQIVLPRDSYLQGYFDNTTEYLRVGPPLYFVVKDYNYSSESRHTNQLCSISQCDSNSLLNEISRASSIPELSYIAKPAASWLDDFLVWTSPEAFGCCRKFVNGTYXXXXXXXXXXXXXXXXXGVNGVCKDCTTC---------FRHSDLVNNRPSTEQFMEKLPWFLNALPSADCAKGGHGAYSTSVDLNGYESGIIQASEFRTFHTPL--NKQXDLCNSLRAARXVSSRMSDTL 719
            + LS++I  G +Q +     SY+  +F    ++  VGPP++F V            N+ C+   C   S  N ++ A    E +Y++    +W+D++L W S ++  CC+ +V+                          K C TC         +  S ++ +RPS E F   L  FL   P+++C  GG  ++  ++       G IQAS+F TFH  L  +   D   ++  AR VS R+  ++
Sbjct:  870 VILSSKISVGFDQSMAFTEKSYISTHFRYLDKFFDVGPPVFFTVDGELDWHRPDVQNKFCTFPGCSDTSFGNIMNYAVGHTEQTYLSGEMYNWIDNYLEWISRKS-PCCKVYVHDPNTFCSTNRNKSALDD---------KACRTCMDFDYVANSYPKSSIMYHRPSIEVFYRHLRHFLEDTPNSECVFGGRASFKDAISFT--SRGRIQASQFMTFHKKLSISNSSDFIKAMDTARMVSRRLERSI 1104